Patients with ischemic stroke (IS) who have a proximal major cerebral artery occlusion within 6 hours of the onset of symptoms are treated with mechanical thrombectomy (MT). If the patient qualifies, IV tissue plasminogen activator (TPA) and thrombectomy are the treatments for an MCA stroke. In patients with anterior circulation ELVO and an NIHSS score of 3, thrombectomy is recommended. In addition to changes owing to direct tissue damage to the insula and basal ganglia, a right MCA stroke may impair the feeling of pleasurable emotions via affecting brain activity in limbic and paralimbic regions far from the location of direct damage. The fast onset of a focused neurologic deficit caused by a brain infarction or ischemia in the territory supplied by the MCA is known as an MCA stroke. The MCA is the largest cerebral artery by far, and it is the artery most usually injured by a stroke. The MCA's principal job is to provide oxygenated blood to specific areas of the brain parenchyma. Apart from the insular and auditory cortex, the MCA's cortical branches nourish the brain parenchyma of the key motor and somatosensory cortical areas of the face, trunk, and upper limbs. Mechanical thrombectomy is a minimally invasive technique in which an interventional radiologist removes a clot from a patient's artery using specialized equipment.